Protein name:
Interleukin-15 (IL-15) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Function:
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
Subcellular Location:
Isoform IL15-S21AA
Cytoplasm
Nucleus
IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
Protein Attributes:
50:
MRISKPHLRS | ISIQCYLCLL | LNSHFLTEAG | IHVFILGCFS | AGLPKTEANW |
100:
VNVISDLKKI | EDLIQSMHID | ATLYTESDVH | PSCKVTAMKC | FLLELQVISL |
150:
ESGDASIHDT | VENLIILANN | SLSSNGNVTE | SGCKECEELE | EKNIKEFLQS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Pig
Rabbit
Rat
ELISA Kit for Human IL-15
ELISA Kit for Human IL-15
ELISA Kit for Human IL-15
ELISA Kit for Human IL-15
ELISA Kit for Human IL-15
ELISA Kit for Human IL-15
Polyclonal Antibody for Human IL-15
Polyclonal Antibody for Human IL-15
Polyclonal Antibody for Human IL-15
Polyclonal Antibody for Human IL-15
Polyclonal Antibody for Human IL-15
Polyclonal Antibody for Human IL-15
Monoclonal Antibody for Human IL-15
Monoclonal Antibody for Human IL-15
Monoclonal Antibody for Human IL-15
Monoclonal Antibody for Human IL-15
Monoclonal Antibody for Human IL-15
Monoclonal Antibody for Human IL-15
R&D Technical Data
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12% SDS-PAGE Analysis
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Precision
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Recovery
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Linearity
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References
1.
"Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor."
Grabstein K.H.
,
Eisenman J.
,
Shanebeck K.
,
Rauch C.
,
Srinivasan S.
,
Fung V.
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Science264:965-968(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S48AA)
tissue :
Bone marrow .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S21AA)
tissue :
Lung cancer .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S21AA)
tissue :
Testis .
5.
"Expression of two IL-15 mRNA isoforms in human tumors does not correlate with secretion: role of different signal peptides."
Meazza R.
,
Ferrini S.
Submitted (1997-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
6.
Li C.
Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S21AA)
7.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IL15-S21AA)
tissue :
Cerebellum .
tissue :
Heart .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IL15-S21AA)
9.
Mural R.J.
,
Istrail S.
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Sutton G.G.
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Florea L.
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Halpern A.L.
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Dew I.
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Edwards N.J.
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Bolanos R.
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Fasulo D.
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Halldorsson B.V.
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Hannenhalli S.
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Turner R.
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Yooseph S.
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Lu F.
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Nusskern D.R.
,
Shue B.C.
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Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
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Waterman M.S.
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Eichler E.E.
,
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,
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,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS IL15-S48AA AND IL15-S21AA)
tissue :
Colon .
11.
"IL15 expression in human keratinocytes."
Sorel M.A.
,
Jacques Y.
Submitted (1994-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 49-162
tissue :
Epidermis .
12.
"Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an alpha-helix in VH CDR3 as key component of paratope."
Lowe D.C.
,
Gerhardt S.
,
Ward A.
,
Hargreaves D.
,
Anderson M.
,
Ferraro F.
,
Pauptit R.A.
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,
Wilkinson T.
,
Sleeman M.
,
Vaughan T.J.
,
Mallinder P.R.
J. Mol. Biol.406:160-175(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 49-162 IN COMPLEX WITH ANTIBODY;DISULFIDE BONDS